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"The victim of gout may show remarkable mental and even bodily vigor. Certain of the most distinguished members of our profession have been terrible sufferers from this disease, notably the elder Scaliger, Jerome Cardan, and Sydenham, whose statement that 'more wise men than fools are victims of the affection' still holds good."

Notes:

  1. In the 8th edition of Principles and Practice (1912), Osler reversed himself, saying: "Among distinguished members of our profession who have been terrible sufferers were the elder Scaliger, Jerome Cardan and Sydenham. The statement of the latter, however, that 'more wise men than fools are victims' of the affection, does not hold good to-day."

  2. H. E. MacDermot cited the following speculation as to why Osler made this change: "Dr. Malloch thinks that the change was made because Sir William had come to realize that he himself was experiencing the 'lispings,' reference to which is made in all the editions…" (MacDermot HE. Notes on the early editions of Osler's textbook of medicine. Ann Med Hist 6:224-240, 1934.)

  3. "A common gouty manifestation, upon which Duckworth has laid stress, is the occurrence of hot or itching feet at night. Plutarch mentions that Strabo called this symptom 'the lisping of the gout.'" (Principles and Practice of Medicine, 4th edition.)

  4. Sydenham, Thomas